COCKAYNE SYNDROME LINKED TO ELEVATED R-LOOPS INDUCED BY STALLED RNA POLYMERASE II DURING TRANSCRIPTION ELONGATION

Cockayne Syndrome Linked to Elevated R-Loops Induced by Stalled RNA Polymerase II during Transcription Elongation

Abstract Mutations in the Cockayne Syndrome group B (CSB) gene cause cancer in mice, but premature aging and severe neurodevelopmental defects in humans.CSB, a member of the SWI/SNF family of chromatin remodelers, plays diverse roles in regulating gene expression Mens Bags and transcription-coupled nucleotide excision repair (TC-NER); however, thes

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Data science: connotation, methods, technologies, and development

The rapid development of big data breeds data science.Understanding and mastering the internal pattern of the value generation of big data is important for improving digitization and the covergence of data science with management science, computer science, and other disciplines.In this study, we discuss the significance of data science for the deve

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